Pearse A Keane,1 Gabriella de Salvo,2 Dawn Brides A Sim,1 Srini Goverdhan,2 Rupesh Agrawal,1 Adnan Tufail1 1NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, 2Department of Ophthalmology, University Hospital Southampton NHS Foundation Trust, Southampton, UK Ab

IntroductionBroad Brush Surveys (BBS) are a rapid, qualitative assessment approach using four meta-indicators -physical features, social organization, Rolling Tray social networks and community narratives - to gauge how local context interfaces with service/intervention options, implementation and uptake.MethodsIn 2021, responding to rapid urbaniza

Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold.It functions as a mediator of keratinocyte mechanical stability in the skin, primarily through linking intermediate filaments to Brides hemidesmosomes.Skin fragi

It is well known that slipping in automotive clutches is closely related to the concave deformation of the pressure plate, but the mechanism of this deformation is not clear.A simplified model of a pressure plate assembly is developed by simulating the deformation field of the plate under the condition of continuous sliding, followed by natural coo

ABSTRACT Human parainfluenza virus 3 (HPIV3) infection is driven by the coordinated action of viral surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion protein (F).Receptor-engaged HN activates F to insert into the target cell membrane and drive virion-cell membrane fusion.For F to mediate entry, its precursor (F0) must first be cleav